Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23950391 | 0.74 | PIK3CD (0.37) | DPP4DPP7BMPR1AACVRL1ACVR1 | |
| SCHEMBL17120437 | 0.74 | ALDH1A1 (0.51) | DPP4DPP7BMPR1AACVRL1ACVR1 | |
| SCHEMBL120724 | 0.74 | HTR7 (0.39) | THRBBMPR1AACVRL1ACVR1KMT2A | |
| SCHEMBL17522927 | 0.73 | DPP4 (0.33) | DPP4DPP7BMPR1AACVRL1ACVR1 | |
| SCHEMBL21653118 | 0.71 | ALDH1A1 (0.38) | ADORA2BCYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL21350503 | 0.70 | MAPT (0.48) | DPP4DPP7BMPR1AACVRL1ACVR1 | |
| SCHEMBL13875960 | 0.69 | DPP4 (0.37) | DPP4DPP7BMPR1AACVRL1ACVR1 | |
| SCHEMBL15719392 | 0.69 | SIGMAR1 (0.49) | KCNH2KMT2A | |
| SCHEMBL16465276 | 0.68 | BMPR1A (0.41) | THRBBMPR1AACVRL1ACVR1KDM4E | |
| SCHEMBL24583674 | 0.68 | MAPT (0.49) | BMPR1AACVRL1ACVR1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021209552-A1 | PYRAZOLO[1,5-D][1,2,4]TRIAZINE-5(4H)-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-21 | — | — | WO | disclosed |