Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25241958 | 0.77 | MCHR1 (0.47) | MCHR1ALDH1A1SCN10AKDM4ENPC1 | |
| SCHEMBL2127565 | 0.75 | ALDH1A3 (0.57) | ALDH1A1KDM4ENPC1HPGDRAB9A | |
| SCHEMBL23950992 | 0.71 | PIK3CG (0.38) | MCHR1ALDH1A1SCN10AKDM4ENPC1 | |
| SCHEMBL23950206 | 0.70 | MCHR1 (0.47) | MCHR1ALDH1A1SCN10AKDM4ENPC1 | |
| SCHEMBL4441720 | 0.67 | MEN1 (0.47) | MCHR1ALDH1A1HPGDNFKB1 | |
| SCHEMBL12832006 | 0.62 | SMN1; SMN2 (0.53) | ALDH1A1KDM4ENPC1HPGDRAB9A | |
| SCHEMBL14701600 | 0.61 | MCHR1 (0.59) | MCHR1ALDH1A1SCN10AKDM4ENPC1 | |
| SCHEMBL469386 | 0.61 | ALDH1A1 (0.72) | ALDH1A1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL90440 | 0.61 | ALDH1A1 (0.56) | ALDH1A1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21033162 | 0.61 | KDM4E (0.40) | MCHR1ALDH1A1KDM4ENPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021209552-A1 | PYRAZOLO[1,5-D][1,2,4]TRIAZINE-5(4H)-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-21 | — | — | WO | disclosed |