Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.38 |
| ▸ | PGR | P06401 | 2/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19156546 | 1.00 | CA12 (0.39) | CA12CA2CA9NR3C1PGR | |
| SCHEMBL20820916 | 0.95 | CA12 (0.40) | CA12CA2CA9SMN1; SMN2MGAT2 | |
| SCHEMBL19853185 | 0.91 | TDO2 (0.41) | ALOX5APFEN1SMN1; SMN2 | |
| SCHEMBL19156557 | 0.88 | CA2 (0.40) | CA12CA2CA9SMN1; SMN2MGAT2 | |
| SCHEMBL19681317 | 0.87 | ALOX5AP (0.46) | CA12CA2CA9ALOX5APFEN1 | |
| SCHEMBL19156928 | 0.87 | ALOX5AP (0.46) | CA12CA2CA9ALOX5APFEN1 | |
| SCHEMBL19156975 | 0.83 | MMP1 (0.46) | CA12CA2CA9ALOX5APFEN1 | |
| SCHEMBL18744727 | 0.82 | TDO2 (0.40) | CA12CA2CA9ALOX5APFEN1 | |
| SCHEMBL12508301 | 0.77 | ALOX5AP (0.46) | ALOX5APFEN1SMN1; SMN2 | |
| SCHEMBL19156961 | 0.76 | KIT (0.39) | CA12CA2CA9ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3262028-B1 | N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-PHENYL-BENZENESULFONAMIDE AND N-(-4HYDROXY-4-METHYL-CYCLOHEXYL)-4-(2-PYRIDYL)-BENZENESULFONAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE | PIMCO 2664 LTD (GB) | 2021-10-27 | — | — | EP | disclosed |