Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | SRD5A1 | P18405 | 10/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 2/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29481934 | 1.00 | P2RX7 (0.42) | P2RX7METAP1SRD5A1SRD5A2SMN1; SMN2 | |
| SCHEMBL4307204 | 0.93 | CYP11B2 (0.44) | P2RX7METAP1SRD5A1SRD5A2SMN1; SMN2 | |
| SCHEMBL13136752 | 0.84 | SRD5A1 (0.50) | P2RX7SRD5A1SRD5A2SMN1; SMN2LMNA | |
| SCHEMBL1956260 | 0.83 | GAA (0.55) | P2RX7METAP1SRD5A1SRD5A2SMN1; SMN2 | |
| SCHEMBL21603396 | 0.79 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNAGAACYP11B2HSD17B3 | |
| SCHEMBL21183690 | 0.79 | BRD4 (0.54) | METAP1SRD5A1SMN1; SMN2AHRCMA1 | |
| SCHEMBL28619979 | 0.79 | TDP2 (0.41) | SRD5A1SMN1; SMN2GAACYP11B2 | |
| SCHEMBL29481924 | 0.78 | METAP1 (0.39) | P2RX7METAP1SRD5A1SRD5A2AHR | |
| SCHEMBL23957214 | 0.78 | METAP1 (0.39) | P2RX7METAP1SRD5A1SRD5A2AHR | |
| SCHEMBL13637299 | 0.76 | HSP90AA1 (0.38) | SMN1; SMN2LMNAGAACYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116425678-A | Hydrochloride of aminocyclobutane derivative and crystal form and preparation thereof | 苏州恩华生物医药科技有限公司 | 2023-07-14 | — | — | CN | disclosed |
| CN-116425677-A | Salts of aminocyclobutane derivatives, crystalline forms thereof, and preparation methods and applications thereof | 苏州恩华生物医药科技有限公司 | 2023-07-14 | — | — | CN | disclosed |
| CN-114269747-B | 1',2' -dihydro-3'H-spiro [ cyclobutane 1,4' -isoquinoline ] -3' -one derivative and application thereof | 苏州恩华生物医药科技有限公司 | 2023-04-18 | — | — | CN | disclosed |
| CN-114269747-A | 1 ', 2 ' -dihydro-3 ' H-spiro [ cyclobutane 1,4 ' -isoquinoline ] -3 ' -ketone derivative and application thereof | 苏州恩华生物医药科技有限公司 | 2022-04-01 | — | — | CN | disclosed |
| WO-2021213353-A1 | AMIDE OR SULFONAMIDE DERIVATIVE AND USE THEREOF | 苏州恩华生物医药科技有限公司 (CN) | 2021-10-28 | — | — | WO | disclosed |