Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 2/20 | 0.41 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | NEK2 | P51955 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2839028 | 0.80 | METAP1 (0.43) | SRD5A1GAASMN1; SMN2CYP11B2DPP7 | |
| SCHEMBL21183690 | 0.79 | BRD4 (0.54) | TDP2SRD5A1GAASMN1; SMN2CYP11B2 | |
| SCHEMBL21603396 | 0.79 | SMN1; SMN2 (0.42) | GAASMN1; SMN2CYP11B2BRD4 | |
| SCHEMBL23957375 | 0.79 | P2RX7 (0.42) | SRD5A1GAASMN1; SMN2CYP11B2 | |
| SCHEMBL29481934 | 0.79 | P2RX7 (0.42) | SRD5A1GAASMN1; SMN2CYP11B2 | |
| SCHEMBL13637299 | 0.76 | HSP90AA1 (0.38) | GAASMN1; SMN2CYP11B2ACHE | |
| SCHEMBL677618 | 0.75 | BRD4 (0.50) | CYP11B2BRD4CREBBPNOTUMACHE | |
| SCHEMBL9922266 | 0.74 | TDP2 (0.51) | TDP2SRD5A1GAACASP3PDE3B | |
| SCHEMBL21603408 | 0.73 | LMNA (0.47) | TDP2GAASMN1; SMN2DPP7CASP3 | |
| SCHEMBL1441245 | 0.73 | CASP3 (0.43) | TDP2SRD5A1CASP3PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113234079-B | Nucleoside analogs as PRMT5 inhibitors | 上海湃隆生物科技有限公司 | 2022-02-01 | — | — | CN | disclosed |
| CN-113234079-A | Nucleoside analogs as PRMT5 inhibitors | 上海湃隆生物科技有限公司 | 2021-08-10 | — | — | CN | disclosed |