Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | KMO | O15229 | 3/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.43 |
| ▸ | CASP1 | P29466 | 4/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | HCK | P08631 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL23931703 | 0.99 | MKNK2 (0.48) | MKNK2MKNK1KMOLOXL2MAP4K4 | |
| SCHEMBL23931758 | 0.89 | MKNK2 (0.49) | MKNK2MKNK1KMOLOXL2MAP4K4 | |
| SCHEMBL23931720 | 0.85 | MKNK2 (0.48) | MKNK2MKNK1LOXL2MAP4K4ABL1 | |
| Hydrochloric Acid SCHEMBL30267091 | 0.84 | MKNK2 (0.47) | MKNK2MKNK1LOXL2MAP4K4ABL1 | |
| Hydrochloric Acid SCHEMBL23931772 | 0.84 | MKNK2 (0.47) | MKNK2MKNK1LOXL2MAP4K4ABL1 | |
| SCHEMBL30492056 | 0.83 | MKNK1 (0.43) | MKNK2MKNK1KMOLOXL2MAP4K4 | |
| SCHEMBL23931722 | 0.83 | MKNK1 (0.43) | MKNK2MKNK1KMOLOXL2MAP4K4 | |
| Hydrochloric Acid SCHEMBL4427907 | 0.78 | KMO (0.53) | KMOLOXL2PIK3CAPIK3CB | |
| SCHEMBL23931796 | 0.78 | MAOB (0.49) | CASP1 | |
| SCHEMBL30267398 | 0.78 | MAOB (0.49) | CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234925-A1 | GPR52 MODULATORS AND METHODS OF USE | NEUROCRINE BIOSCIENCES, INC. | 2023-07-27 | — | — | US | disclosed |
| WO-2021216705-A1 | GPR52 MODULATORS AND METHODS OF USE | NEUROCRINE BIOSCIENCES, INC. (US) | 2021-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234925-A1 | GPR52 MODULATORS AND METHODS OF USE | GPR52, GPR68, GPR35 | MKNK2 2806/4885MKNK1 3584/4885KMO 1707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.