Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.45 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL851497 | 0.87 | L3MBTL1 (0.60) | MAPTTDP1L3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL2965072 | 0.86 | CHRM4 (0.48) | MAPTTDP1L3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL2394509 | 0.86 | MAPT (0.56) | MAPTTDP1L3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL12310656 | 0.80 | CNR1 (0.40) | MAPTALDH1A1HDAC6SMPD1 | |
| SCHEMBL880181 | 0.79 | MAPT (0.44) | MAPTTDP1L3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL880178 | 0.77 | MAPT (0.43) | MAPTTDP1L3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL6519468 | 0.77 | MAPT (0.43) | MAPTTDP1L3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL6518890 | 0.77 | MAPT (0.43) | MAPTTDP1L3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL6518886 | 0.77 | MAPT (0.43) | MAPTTDP1L3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL22568217 | 0.76 | NPC1 (0.56) | MAPTL3MBTL1SMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492440-B2 | Difluorophenyldiacylhydrazide derivatives | MERCK PATENT GMBH (DE) | 2013-07-23 | — | — | US | disclosed |
| US-20110224302-A1 | DIFLUOROPHENYLDIACYLHYDRAZIDE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224302-A1 | DIFLUOROPHENYLDIACYLHYDRAZIDE DERIVATIVES | FGFR1, PKD1, AGTR1 | MAPT 4485/4885TDP1 1922/4885L3MBTL1 669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.