Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SGMS2 | Q8NHU3 | 3/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1843333 | 0.87 | CLCN2 (0.55) | CHRM4CHRM3CLCN2MCL1MAPT | |
| SCHEMBL2396534 | 0.86 | MAPT (0.55) | HDAC6MAPTALDH1A1KDM4ECYP2C9 | |
| SCHEMBL23067188 | 0.81 | HDAC6 (0.51) | CHRM4CHRM3CLCN2HDAC6MCL1 | |
| SCHEMBL29557588 | 0.81 | HDAC6 (0.51) | CHRM4CHRM3CLCN2HDAC6MCL1 | |
| SCHEMBL28731423 | 0.80 | HDAC6 (0.57) | CHRM4CHRM3CLCN2HDAC6MAPT | |
| SCHEMBL21447041 | 0.76 | NPC1 (0.58) | HDAC6MAPTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL17041323 | 0.76 | KMT2A (0.65) | HDAC6ALDH1A1CYP2C9KMT2ASGMS2 | |
| SCHEMBL22568217 | 0.75 | NPC1 (0.56) | HDAC6MAPTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL6748166 | 0.75 | SGMS2 (0.72) | MAPTALDH1A1L3MBTL1KMT2ASGMS2 | |
| SCHEMBL11819948 | 0.75 | SMN1; SMN2 (0.54) | CHRM4CHRM3CLCN2MCL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776920-B2 | Mandelic hydrazides | MERCK PATENT GMBH (DE) | 2010-08-17 | — | — | US | disclosed |
| US-20090221712-A1 | MANDELIC HYDRAZIDES | MERCK PATENT GESELLSCHAFT (DE) | 2009-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221712-A1 | MANDELIC HYDRAZIDES | HK1, GLS, AGK | CHRM4 660/4885CHRM3 541/4885CLCN2 1746/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.