Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 | O95136 | 10/20 | 0.65 |
| ▸ | RHEB | Q15382 | 3/20 | 0.38 |
| ▸ | F9 | P00740 | 3/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | BRS3 | P32247 | 1/20 | 0.32 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23966815 | 0.92 | S1PR2 (0.63) | S1PR2RHEBCYP3A4CYP2C9 | |
| SCHEMBL23908839 | 0.92 | S1PR2 (0.75) | S1PR2RHEB | |
| SCHEMBL23914704 | 0.92 | S1PR2 (0.62) | S1PR2RHEB | |
| SCHEMBL23908779 | 0.86 | S1PR2 (0.65) | S1PR2RHEBTP53 | |
| SCHEMBL23966848 | 0.85 | S1PR2 (0.72) | S1PR2RHEBTP53EGFR | |
| SCHEMBL23966844 | 0.78 | S1PR2 (0.70) | S1PR2RHEBCYP3A4CYP2C9 | |
| SCHEMBL23966531 | 0.77 | S1PR2 (0.87) | S1PR2CYP3A4CYP2C9TP53 | |
| SCHEMBL23908918 | 0.77 | S1PR2 (0.69) | S1PR2RHEB | |
| SCHEMBL23915575 | 0.77 | S1PR2 (0.69) | S1PR2F9CYP3A4CYP2C9TP53 | |
| SCHEMBL23966552 | 0.77 | S1PR2 (0.84) | S1PR2RHEB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3649119-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2021-11-03 | — | — | EP | disclosed |