Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 | O95136 | 10/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | GRK5 | P34947 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23966848 | 0.93 | S1PR2 (0.72) | S1PR2RHEBNLRP3 | |
| SCHEMBL23966552 | 0.91 | S1PR2 (0.84) | S1PR2RHEBNLRP3 | |
| SCHEMBL23908918 | 0.91 | S1PR2 (0.69) | S1PR2RHEBNLRP3 | |
| SCHEMBL23966815 | 0.85 | S1PR2 (0.63) | S1PR2L3MBTL1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL23914869 | 0.85 | S1PR2 (0.72) | S1PR2RHEB | |
| SCHEMBL23966530 | 0.81 | S1PR2 (0.82) | S1PR2L3MBTL1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL23966542 | 0.80 | S1PR2 (0.82) | S1PR2L3MBTL1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL23914638 | 0.80 | S1PR2 (0.80) | S1PR2RHEB | |
| SCHEMBL23914868 | 0.80 | S1PR2 (0.66) | S1PR2CYP1A2CYP2C9NLRP3 | |
| SCHEMBL23908887 | 0.79 | S1PR2 (0.94) | S1PR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3649119-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2021-11-03 | — | — | EP | disclosed |