Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 4/20 | 0.40 |
| ▸ | KDM5A | P29375 | 4/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.33 |
| ▸ | RHEB | Q15382 | 2/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.31 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.31 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.31 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.31 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.31 |
| ▸ | TFDP2 | Q14188 | 1/20 | 0.31 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.31 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
| ▸ | GUSB | P08236 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16069452 | 0.89 | KDM4A (0.46) | KDM4AKDM5AKDM5BPRKAG1PRKAA2 | |
| SCHEMBL17402604 | 0.83 | HAVCR2 (0.39) | KDM4AKDM5AKDM5BIMPDH2RHEB | |
| SCHEMBL23967852 | 0.79 | PRKAG1 (0.45) | KDM4AKDM5AKDM5BRHEBCHEK2 | |
| SCHEMBL17402602 | 0.77 | PTGS2 (0.41) | — | |
| SCHEMBL17402603 | 0.76 | PRKAG1 (0.40) | RHEBPRKAG1PRKAA2PRKAB1PRKAB2 | |
| SCHEMBL17402637 | 0.75 | PRKAB2 (0.45) | KDM4AKDM5AKDM5BRHEBCHEK2 | |
| SCHEMBL16069459 | 0.74 | PRKAG1 (0.47) | KDM4AKDM5AKDM5BPRKAG1PRKAA2 | |
| SCHEMBL16069896 | 0.73 | PRKAG1 (0.43) | KDM4AKDM5AKDM5BPRKAG1PRKAA2 | |
| SCHEMBL17391579 | 0.73 | MAPK14 (0.43) | KDM4AKDM5AKDM5BPRKAG1PRKAA2 | |
| SCHEMBL16069464 | 0.72 | PRKAG1 (0.54) | KDM4AKDM5AKDM5BPRKAG1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970119-B1 | NOVEL INDOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS | MERCK SHARP & DOHME (US) | 2021-11-03 | — | — | EP | disclosed |