Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 10/20 | 0.45 |
| ▸ | PRKAA2 | P54646 | 10/20 | 0.45 |
| ▸ | PRKAB1 | Q9Y478 | 10/20 | 0.45 |
| ▸ | PRKAB2 | O43741 | 7/20 | 0.45 |
| ▸ | PRKAA1 | Q13131 | 7/20 | 0.45 |
| ▸ | PRKAG3 | Q9UGI9 | 7/20 | 0.45 |
| ▸ | PRKAG2 | Q9UGJ0 | 7/20 | 0.45 |
| ▸ | RHEB | Q15382 | 2/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.32 |
| ▸ | TFDP2 | Q14188 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16069468 | 0.88 | PRKAG1 (0.55) | PRKAG1PRKAA2PRKAB1PRKAB2PRKAA1 | |
| SCHEMBL17402604 | 0.83 | HAVCR2 (0.39) | PRKAG1PRKAA2PRKAB1PRKAB2PRKAA1 | |
| SCHEMBL17402637 | 0.81 | PRKAB2 (0.45) | PRKAG1PRKAA2PRKAB1PRKAB2PRKAA1 | |
| SCHEMBL17402602 | 0.81 | PTGS2 (0.41) | — | |
| SCHEMBL17402603 | 0.80 | PRKAG1 (0.40) | PRKAG1PRKAA2PRKAB1PRKAB2PRKAA1 | |
| SCHEMBL23967636 | 0.79 | KDM4A (0.40) | PRKAG1PRKAA2PRKAB1PRKAB2PRKAA1 | |
| SCHEMBL16069464 | 0.76 | PRKAG1 (0.54) | PRKAG1PRKAA2PRKAB1PRKAB2PRKAA1 | |
| SCHEMBL16069459 | 0.74 | PRKAG1 (0.47) | PRKAG1PRKAA2PRKAB1PRKAB2PRKAA1 | |
| SCHEMBL23967846 | 0.73 | FFAR1 (0.45) | FFAR1PPARG | |
| SCHEMBL16069469 | 0.73 | PRKAG1 (0.42) | PRKAG1PRKAA2PRKAB1PRKAB2PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970119-B1 | NOVEL INDOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS | MERCK SHARP & DOHME (US) | 2021-11-03 | — | — | EP | disclosed |