Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 4/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15987016 | 0.85 | HSD17B10 (0.35) | ITGB3ITGA2BHSD17B10CYP1A2 | |
| SCHEMBL23906369 | 0.84 | ITGB3 (0.40) | ITGB3ITGA2BHSD17B10CYP2D6CYP3A4 | |
| SCHEMBL23968808 | 0.82 | ITGB3 (0.37) | ITGB3ITGA2BHSD17B10CYP1A2CYP2D6 | |
| SCHEMBL23896280 | 0.82 | ITGB3 (0.37) | ITGB3ITGA2BHSD17B10CYP1A2CYP2D6 | |
| SCHEMBL14671193 | 0.81 | ITGB3 (0.42) | ITGB3ITGA2BHSD17B10CYP2D6CYP3A4 | |
| SCHEMBL15986980 | 0.79 | CYP1A2 (0.41) | ITGB3ITGA2BHSD17B10CYP1A2 | |
| SCHEMBL23906394 | 0.79 | ITGB3 (0.37) | ITGB3ITGA2BHSD17B10 | |
| SCHEMBL20793573 | 0.79 | ITGB3 (0.38) | ITGB3ITGA2BHSD17B10CYP2D6CYP3A4 | |
| SCHEMBL20793493 | 0.79 | ITGB3 (0.38) | ITGB3ITGA2BHSD17B10CYP2D6CYP3A4 | |
| SCHEMBL20793574 | 0.79 | TSHR (0.42) | ITGB3ITGA2BHSD17B10CYP2D6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11161856-B2 | Spirocycle compounds and methods of making and using same | H. LUNDBECK A/S (DK) | 2021-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11161856-B2 | Spirocycle compounds and methods of making and using same | OPRL1, MGLL, VKORC1L1 | ITGB3 4443/4885ITGA2B 4042/4885HSD17B10 670/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.