Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 3/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.35 |
| ▸ | USP2 | O75604 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14671076 | 0.87 | HSD17B10 (0.32) | TSHRHSD17B10ALDH1A1 | |
| SCHEMBL25547732 | 0.84 | ITGB3 (0.35) | ITGB3ITGA2BTSHRCYP2D6CYP3A4 | |
| SCHEMBL23968807 | 0.82 | ITGB3 (0.40) | ITGB3ITGA2BTSHRCYP2D6CYP3A4 | |
| SCHEMBL14671064 | 0.81 | ITGB3 (0.35) | ITGB3ITGA2B | |
| SCHEMBL14670912 | 0.81 | ITGB3 (0.36) | ITGB3ITGA2BTSHRCYP2D6HSD17B10 | |
| SCHEMBL23906369 | 0.80 | ITGB3 (0.40) | ITGB3ITGA2BTSHRCYP2D6CYP3A4 | |
| SCHEMBL19992848 | 0.79 | TSHR (0.36) | ITGB3ITGA2BTSHRCYP2D6CYP3A4 | |
| SCHEMBL23365958 | 0.78 | TSHR (0.46) | TSHRCYP2D6CYP3A4CYP1A2USP2 | |
| SCHEMBL23896280 | 0.78 | ITGB3 (0.37) | ITGB3ITGA2BTSHRCYP2D6CYP3A4 | |
| SCHEMBL20793670 | 0.78 | HRH3 (0.36) | ITGB3ITGA2BTSHRCYP2D6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11161856-B2 | Spirocycle compounds and methods of making and using same | H. LUNDBECK A/S (DK) | 2021-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11161856-B2 | Spirocycle compounds and methods of making and using same | OPRL1, MGLL, VKORC1L1 | ITGB3 4443/4885ITGA2B 4042/4885TSHR 4381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.