Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11843852 | 0.77 | HSD11B1 (0.37) | HSD11B1KDM4EKMT2ALMNAMAPT | |
| SCHEMBL12627977 | 0.72 | TSHR (0.60) | HSD11B1KDM4EKMT2ALMNAMAPT | |
| SCHEMBL18413732 | 0.72 | ALDH1A1 (0.36) | HSD11B1KDM4EKMT2AALDH1A1 | |
| SCHEMBL18529420 | 0.70 | HSD11B1 (0.41) | HSD11B1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL11448924 | 0.67 | HSD11B1 (0.53) | HSD11B1KDM4EKMT2ALMNAALDH1A1 | |
| SCHEMBL5092260 | 0.65 | HSD11B1 (0.81) | HSD11B1KMT2AALDH1A1 | |
| SCHEMBL17243992 | 0.65 | MEN1 (0.38) | KDM4EKMT2AALDH1A1 | |
| SCHEMBL23118249 | 0.64 | SLC22A12 (0.35) | HSD11B1 | |
| SCHEMBL2160231 | 0.64 | ALDH1A1 (0.48) | HSD11B1KMT2ALMNAALDH1A1 | |
| SCHEMBL24610230 | 0.63 | AVPR1A (0.50) | KDM4EKMT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3903788-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | Taisho Pharmaceutical Co., Ltd. (JP) | 2021-11-03 | — | — | EP | disclosed |