Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 7/20 | 0.32 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.32 |
| ▸ | TYR | P14679 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22175908 | 0.88 | SIGMAR1 (0.37) | PLK1PLK3TYRMEN1TP53 | |
| SCHEMBL22176523 | 0.88 | SIGMAR1 (0.37) | PLK1PLK3TYRMEN1TP53 | |
| SCHEMBL22175863 | 0.88 | SIGMAR1 (0.37) | PLK1PLK3TYRMEN1TP53 | |
| SCHEMBL22176363 | 0.86 | MPO (0.46) | HRH4HRH3CHRM2MPOTYR | |
| SCHEMBL22175858 | 0.86 | L3MBTL4 (0.38) | MPOPLK1PLK3TDP1 | |
| SCHEMBL23969349 | 0.82 | CNR1 (0.38) | HRH4HRH3KMT2A | |
| SCHEMBL23969391 | 0.82 | TAAR1 (0.37) | TYRMEN1TP53CYP3A4ALOX5 | |
| SCHEMBL23969340 | 0.82 | TAAR1 (0.37) | TYRMEN1TP53CYP3A4ALOX5 | |
| SCHEMBL22175910 | 0.79 | MPO (0.46) | HRH4HRH3CHRM2MPOTYR | |
| SCHEMBL23969319 | 0.77 | TAAR1 (0.31) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3903788-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | Taisho Pharmaceutical Co., Ltd. (JP) | 2021-11-03 | — | — | EP | disclosed |