Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CRHBP | P24387 | 2/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22176312 | 0.83 | SIGMAR1 (0.47) | SIGMAR1L3MBTL1KMT2AKDM4EHPGD | |
| SCHEMBL22175908 | 0.80 | SIGMAR1 (0.37) | SIGMAR1L3MBTL1KMT2AKDM4EHPGD | |
| SCHEMBL22176523 | 0.80 | SIGMAR1 (0.37) | SIGMAR1L3MBTL1KMT2AKDM4EHPGD | |
| SCHEMBL23969212 | 0.80 | SIGMAR1 (0.37) | SIGMAR1L3MBTL1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL22175863 | 0.80 | SIGMAR1 (0.37) | SIGMAR1L3MBTL1KMT2AKDM4EHPGD | |
| SCHEMBL22176518 | 0.78 | MPO (0.42) | SIGMAR1L3MBTL1KMT2AMEN1HTT | |
| SCHEMBL22175847 | 0.78 | SIGMAR1 (0.40) | SIGMAR1L3MBTL1KMT2AKDM4EHPGD | |
| SCHEMBL22175865 | 0.78 | MPO (0.42) | SIGMAR1L3MBTL1KMT2AMEN1HTT | |
| SCHEMBL22175858 | 0.78 | L3MBTL4 (0.38) | SIGMAR1L3MBTL1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL22175890 | 0.77 | SIGMAR1 (0.33) | SIGMAR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3903788-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | Taisho Pharmaceutical Co., Ltd. (JP) | 2021-11-03 | — | — | EP | disclosed |