Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.37 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | PLK1 | P53350 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.30 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22176523 | 0.89 | SIGMAR1 (0.37) | SIGMAR1L3MBTL4L3MBTL3L3MBTL1PLK1 | |
| SCHEMBL22175863 | 0.89 | SIGMAR1 (0.37) | SIGMAR1L3MBTL4L3MBTL3L3MBTL1PLK1 | |
| SCHEMBL22175908 | 0.89 | SIGMAR1 (0.37) | SIGMAR1L3MBTL4L3MBTL3L3MBTL1PLK1 | |
| SCHEMBL22175858 | 0.87 | L3MBTL4 (0.38) | SIGMAR1L3MBTL4L3MBTL3L3MBTL1PLK1 | |
| SCHEMBL22176518 | 0.85 | MPO (0.42) | SIGMAR1L3MBTL1TDP1 | |
| SCHEMBL22176312 | 0.81 | SIGMAR1 (0.47) | SIGMAR1L3MBTL1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL23969356 | 0.80 | SIGMAR1 (0.43) | SIGMAR1L3MBTL1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL22175890 | 0.78 | SIGMAR1 (0.33) | SIGMAR1L3MBTL1 | |
| SCHEMBL23969324 | 0.78 | PLK1 (0.40) | L3MBTL4L3MBTL3L3MBTL1PLK1ALDH1A1 | |
| SCHEMBL23969232 | 0.77 | HRH4 (0.34) | PLK1TDP1PLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3903788-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | Taisho Pharmaceutical Co., Ltd. (JP) | 2021-11-03 | — | — | EP | disclosed |