Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GBA1 | P04062 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22018814 | 1.00 | PARP1 (0.32) | PARP1ALDH1A1GBA1DPP4 | |
| SCHEMBL22018813 | 1.00 | PARP1 (0.32) | PARP1ALDH1A1GBA1DPP4 | |
| SCHEMBL18399522 | 1.00 | PARP1 (0.32) | PARP1ALDH1A1GBA1DPP4 | |
| SCHEMBL27305028 | 0.88 | DRD2 (0.36) | PARP1 | |
| SCHEMBL24789568 | 0.85 | HRH3 (0.33) | ALDH1A1 | |
| SCHEMBL24789565 | 0.85 | HRH3 (0.33) | ALDH1A1 | |
| SCHEMBL19879501 | 0.83 | OPRK1 (0.30) | DPP4 | |
| SCHEMBL19768960 | 0.83 | OPRK1 (0.30) | DPP4 | |
| SCHEMBL9004988 | 0.83 | OPRK1 (0.30) | DPP4 | |
| SCHEMBL19768934 | 0.83 | OPRK1 (0.30) | DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230002412-A1 | INHIBITORS OF PEPTIDYLARGININE DEIMINASES | GILEAD SCIENCES, INC. | 2023-01-05 | — | — | US | disclosed |
| WO-2021222353-A1 | MACROCYCLIC INHIBITORS OF PEPTIDYLARGININE DEIMINASES | GILEAD SCIENCES, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230002412-A1 | INHIBITORS OF PEPTIDYLARGININE DEIMINASES | PADI4, PADI2, PADI1 | PARP1 313/4885ALDH1A1 2537/4885GBA1 2030/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.