Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL773239 | 0.87 | OPRM1 (0.40) | OPRM1OPRL1 | |
| SCHEMBL3490658 | 0.76 | GAA (0.43) | TSHR | |
| SCHEMBL798410 | 0.76 | OPRM1 (0.38) | OPRM1OPRL1 | |
| SCHEMBL7087554 | 0.76 | DNM1 (0.38) | OPRM1OPRL1TSHR | |
| SCHEMBL6467762 | 0.74 | OPRM1 (0.34) | OPRM1OPRL1 | |
| SCHEMBL4359771 | 0.73 | GAA (0.40) | OPRM1OPRL1TSHR | |
| SCHEMBL6530363 | 0.73 | GRIN2D (0.37) | OPRM1OPRL1TSHR | |
| SCHEMBL1106724 | 0.73 | OPRM1 (0.33) | OPRM1OPRL1 | |
| SCHEMBL882745 | 0.73 | OPRM1 (0.36) | OPRM1OPRL1 | |
| SCHEMBL6463951 | 0.71 | OPRM1 (0.35) | OPRM1OPRL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115551862-B | Macrocyclic inhibitors of peptidyl arginine deiminase | 吉利德科学公司 | 2024-04-12 | — | — | CN | disclosed |
| EP-4143189-A1 | MACROCYCLIC INHIBITORS OF PEPTIDYLARGININE DEIMINASES | GILEAD SCIENCES, INC. (US) | 2023-03-08 | — | — | EP | disclosed |
| CN-115551862-A | Macrocyclic inhibitors of peptidyl arginine deiminase | 吉利德科学公司 | 2022-12-30 | — | — | CN | disclosed |
| WO-2021222353-A1 | MACROCYCLIC INHIBITORS OF PEPTIDYLARGININE DEIMINASES | GILEAD SCIENCES, INC. (US) | 2021-11-04 | — | — | WO | disclosed |