Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTHFD2 | P13995 | 8/20 | 0.41 |
| ▸ | CLPP | Q16740 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.35 |
| ▸ | SPR | P35270 | 3/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | USP9X | Q93008 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30283932 | 1.00 | MTHFD2 (0.41) | MTHFD2CLPPOPRM1OPRD1OPRK1 | |
| SCHEMBL23972479 | 0.95 | MTHFD2 (0.42) | MTHFD2CLPPDGAT2SPRBRD4 | |
| SCHEMBL30284344 | 0.95 | MTHFD2 (0.42) | MTHFD2CLPPDGAT2SPRBRD4 | |
| SCHEMBL30283970 | 0.93 | MTHFD2 (0.37) | MTHFD2CLPPROCK2CYP3A4MAPT | |
| SCHEMBL23973030 | 0.93 | THRB (0.37) | MTHFD2CLPPDGAT2KDRUSP9X | |
| SCHEMBL30283762 | 0.93 | THRB (0.37) | MTHFD2CLPPDGAT2KDRUSP9X | |
| SCHEMBL23972720 | 0.93 | MTHFD2 (0.37) | MTHFD2CLPPROCK2CYP3A4MAPT | |
| SCHEMBL23972403 | 0.92 | MTHFD2 (0.41) | MTHFD2CLPPSPRROCK2CYP3A4 | |
| SCHEMBL30284285 | 0.92 | MTHFD2 (0.41) | MTHFD2CLPPSPRROCK2CYP3A4 | |
| SCHEMBL23973058 | 0.91 | MTHFD2 (0.46) | MTHFD2CLPPDGAT2SPRROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230339934-A1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS | RAQUALIA PHARMA INC. (JP) | 2023-10-26 | — | — | US | disclosed |
| US-20230339934-A1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS | RAQUALIA PHARMA INC. (JP) | 2023-10-26 | — | — | US | disclosed |
| CN-115427409-A | Pyrimidin-4 (3H) -one derivatives as TRPV4 antagonists | 拉夸里亚创药株式会社 | 2022-12-02 | — | — | CN | disclosed |
| WO-2021221169-A1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS | RAQUALIA PHARMA INC. (JP) | 2021-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230339934-A1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS | TRPV4, TRPV1, TRPV2 | MTHFD2 2762/4885CLPP 3447/4885OPRM1 204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.