Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.42 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11299666 | 0.81 | USP30 (0.51) | USP30ALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL11284045 | 0.80 | IL2 (0.57) | USP30ALDH1A1SMN1; SMN2MAPTKDR | |
| SCHEMBL11272742 | 0.78 | USP30 (0.48) | USP30ALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL23221331 | 0.78 | NPC1 (0.51) | USP30ALDH1A1SMN1; SMN2 | |
| SCHEMBL13901759 | 0.76 | RORC (0.69) | ALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL1221497 | 0.74 | NOTUM (0.48) | ALDH1A1SMN1; SMN2MAPTMAPK1 | |
| SCHEMBL2321797 | 0.73 | USP30 (0.51) | USP30ALDH1A1MAPT | |
| SCHEMBL16826161 | 0.72 | LMNA (0.46) | USP30MAPTLMNAMAPK1 | |
| SCHEMBL30438131 | 0.72 | LMNA (0.46) | USP30MAPTLMNAMAPK1 | |
| SCHEMBL965028 | 0.72 | MAPT (0.70) | ALDH1A1SMN1; SMN2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021219089-A1 | SARS-COV-2 INHIBITORS HAVING COVALENT MODIFICATIONS FOR TREATING CORONAVIRUS INFECTIONS | INSILICO MEDICINE IP LIMITED (CN) | 2021-11-04 | — | — | WO | disclosed |