SCHEMBL30438131

SCHEMBL30438131

Cc1cc2n(n1)CCCN2C(=O)CCC(=O)Nc1cc(-c2cccc(C(F)(F)F)c2)no1

nearest known ligand 0.46

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.46
USP30 Q70CQ3 9/20 0.45
TP53 P04637 1/20 0.39
ADORA2A P29274 1/20 0.39
MAPT P10636 1/20 0.38
MAPK1 P28482 1/20 0.38
KCNJ6 P48051 1/20 0.38
KCNJ5 P48544 1/20 0.38
KCNJ3 P48549 1/20 0.38
RECQL P46063 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16826161 1.00 LMNA (0.46) LMNAUSP30TP53ADORA2AMAPT
SCHEMBL16848081 0.91 LMNA (0.46) LMNAUSP30TP53MAPT
SCHEMBL16848105 0.89 LMNA (0.42) LMNAUSP30TP53MAPTMAPK1
SCHEMBL29911888 0.89 RORC (0.43) LMNAUSP30TP53MAPTMAPK1
SCHEMBL16826018 0.89 RORC (0.43) LMNAUSP30TP53MAPTMAPK1
SCHEMBL16826123 0.88 TP53 (0.41) LMNAUSP30TP53MAPTMAPK1
SCHEMBL18169442 0.88 USP30 (0.47) LMNAUSP30TP53MAPT
SCHEMBL16826264 0.88 MAPT (0.51) LMNAUSP30TP53MAPTMAPK1
SCHEMBL16826438 0.86 USP30 (0.53) LMNAUSP30TP53MAPTMAPK1
SCHEMBL16848172 0.85 TP53 (0.41) LMNAUSP30TP53MAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250137069-A1 KIT FOR IDENTIFYING MALIGNANCY, AND USES THEREOF AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2025-05-01 US disclosed
US-12209287-B2 Kit for identifying malignancy, and uses thereof AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2025-01-28 US disclosed
US-20230366031-A1 KIT FOR IDENTIFYING MALIGNANCY, AND USES THEREOF AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2023-11-16 US disclosed
US-11649505-B2 Kit for identifying malignancy, and uses thereof AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2023-05-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11649505-B2 Kit for identifying malignancy, and uses thereof KIT, WNT1, WNT3 LMNA 3171/4885USP30 1963/4885TP53 449/4885
US-12209287-B2 Kit for identifying malignancy, and uses thereof KIT, WNT1, WNT3 LMNA 3171/4885USP30 1963/4885TP53 449/4885
US-20230366031-A1 KIT FOR IDENTIFYING MALIGNANCY, AND USES THEREOF KIT, WNT1, WNT3 LMNA 3171/4885USP30 1963/4885TP53 449/4885
US-20250137069-A1 KIT FOR IDENTIFYING MALIGNANCY, AND USES THEREOF WNT1, KIT, WNT3 LMNA 1575/4885USP30 1035/4885TP53 112/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.