Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | C1R | P00736 | 1/20 | 0.35 |
| ▸ | PNMT | P11086 | 5/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.33 |
| ▸ | TYMS | P04818 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12264350 | 0.87 | PNMT (0.38) | TDP2C1RPNMTADRA2ANPY5R | |
| SCHEMBL15583085 | 0.82 | AVPR1A (0.35) | — | |
| SCHEMBL16591475 | 0.80 | TDP2 (0.40) | TDP2PNMTADRA2ACA12CA1 | |
| SCHEMBL21900260 | 0.65 | KCNH2 (0.39) | NPY5R | |
| SCHEMBL22271650 | 0.63 | TDP2 (0.49) | TDP2PNMTADRA2ACA12CA1 | |
| SCHEMBL261045 | 0.63 | TDP2 (0.39) | TDP2PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL3705905 | 0.63 | TDP2 (0.49) | TDP2PNMTADRA2ACA12CA1 | |
| SCHEMBL260824 | 0.62 | CRBN (0.53) | TDP2PNMTADRA2ACA12CA1 | |
| SCHEMBL5917126 | 0.62 | CA1 (0.47) | TDP2PNMTADRA2ACA12CA1 | |
| SCHEMBL379349 | 0.61 | TDP2 (0.48) | TDP2PNMTADRA2ACA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150087641-A1 | HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. | 2015-03-26 | — | — | US | disclosed |
| EP-2340025-B1 | CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2014-10-15 | — | — | EP | disclosed |
| WO-2013169565-A1 | HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2013-11-14 | — | — | WO | disclosed |
| US-20110224201-A1 | CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2011-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224201-A1 | CGRP RECEPTOR ANTAGONISTS | CCKAR, CALCRL, QRFPR | TDP2 3422/4885C1R 74/4885PNMT 2532/4885 |
| US-20150087641-A1 | HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS | CCKBR, CALCRL, BDKRB2 | TDP2 2128/4885C1R 304/4885PNMT 1262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.