Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL35806 | 0.88 | — | — | |
| SCHEMBL333001 | 0.86 | — | — | |
| SCHEMBL11075197 | 0.84 | — | — | |
| SCHEMBL397518 | 0.83 | CES2 (0.32) | — | |
| SCHEMBL393192 | 0.82 | CES2 (0.34) | — | |
| SCHEMBL395575 | 0.82 | CES2 (0.34) | — | |
| SCHEMBL10537148 | 0.81 | — | — | |
| SCHEMBL16486227 | 0.80 | — | — | |
| SCHEMBL9576543 | 0.80 | — | — | |
| SCHEMBL9576328 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794723-B9 | SILICONE HYDROGELS HAVING A STRUCTURE FORMED VIA CONTROLLED REACTION KINETICS | JOHNSON & JOHNSON VISION CARE (US) | 2019-11-20 | — | — | EP | claimed |
| EP-2794723-B1 | SILICONE HYDROGELS HAVING A STRUCTURE FORMED VIA CONTROLLED REACTION KINETICS | JOHNSON & JOHNSON VISION CARE (US) | 2019-04-24 | — | — | EP | claimed |
| EP-2794725-B1 | SILICONE HYDROGELS COMPRISING N-VINYL AMIDES AND HYDROXYALKYL (METH)ACRYLATES OR (METH)ACRYLAMIDES | JOHNSON & JOHNSON VISION CARE (US) | 2018-07-11 | — | — | EP | claimed |
| EP-2452212-B1 | MONO ETHYLENICALLY UNSATURATED POLYMERIZABLE GROUP CONTAINING POLYCARBOSILOXANE MONOMERS | BAUSCH & LOMB (US) | 2015-03-25 | — | — | EP | claimed |
| EP-2384772-A2 | Antimicrobial lenses, processes to prepare them and methods of their use | Johnson & Johnson Vision Care, Inc. (US) | 2011-11-09 | — | — | EP | disclosed |
| EP-2384773-A1 | Antimicrobial lenses, processes to prepare them and methods of their use | Johnson & Johnson Vision Care, Inc. (US) | 2011-11-09 | — | — | EP | disclosed |
| US-8017665-B2 | Ophthalmic devices containing heterocyclic compounds and methods for their production | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2011-09-13 | — | — | US | disclosed |
| US-20100238399-A1 | OPHTHALMIC DEVICES CONTAINING HETEROCYCLIC COMPOUNDS AND METHODS FOR THEIR PRODUCTION | JOHNSON & JOHNSON VISION CARE, INC. | 2010-09-23 | — | — | US | disclosed |
| US-7767730-B2 | Ophthalmic devices containing heterocyclic compounds and methods for their production | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2010-08-03 | — | — | US | disclosed |
| US-20070196432-A1 | ANTIMICROBIAL LENSES AND METHODS OF THEIR USE | TURNER DAVID C | 2007-08-23 | — | — | US | disclosed |
| US-20070155852-A1 | OPHTHALMIC DEVICES CONTAINING HETEROCYCLIC COMPOUNDS AND METHODS FOR THEIR PRODUCTION | JOHNSON & JOHNSON VISION CARE, INC. | 2007-07-05 | — | — | US | disclosed |
| US-7173073-B2 | Ophthalmic devices containing heterocyclic compounds and methods for their production | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2007-02-06 | — | — | US | disclosed |
| US-20030095230-A1 | Antimicrobial lenses and methods of their use related patent applications | Ido, Koji (JP) | 2003-05-22 | — | — | US | disclosed |
| US-20030044447-A1 | Antimicrobial contact lenses and methods for their production | JOHNSON & JOHNSON VISION CARE, INC. | 2003-03-06 | — | — | US | disclosed |
| US-20030043341-A1 | Antimicrobial lenses and methods of their use | JOHNSON & JOHNSON VISIION CARE, INC. | 2003-03-06 | — | — | US | disclosed |
| US-5331067-A | Acrylic polymers containing trimethylsiloxy groups | PERMEABLE TECHNOLOGIES, INC. (US) | 1994-07-19 | — | — | US | disclosed |
| EP-0525064-A4 | — | — | 1994-04-06 | — | — | EP | disclosed |
| US-5244981-A | Acrylic polymers with pendant silicon containing groups, macromonomers, star polymers | PERMEABLE TECHNOLOGIES, INC. (US) | 1993-09-14 | — | — | US | disclosed |
| EP-0525064-A1 | NOVEL SILICONE-CONTAINING POLYMERS AND OXYGEN PERMEABLE CONTACT LENSES | PERMEABLE TECHNOLOGIES, INC. (US) | 1993-02-03 | — | — | EP | disclosed |
| WO-1991015527-A1 | NOVEL SILICONE-CONTAINING POLYMERS AND OXYGEN PERMEABLE CONTACT LENSES | PERMEABLE CONTACT LENSES, INC. (US) | 1991-10-17 | — | — | WO | disclosed |