Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 5/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 2/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24781339 | 1.00 | CHRNB2 (0.43) | CHRNB2CHRNA4ACHEALDH1A1CYP11B1 | |
| SCHEMBL28560138 | 0.76 | CHRNB2 (0.38) | CHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL15109754 | 0.74 | HTR2A (0.41) | CHRNB2CHRNA4ACHEKDM1A | |
| SCHEMBL16800643 | 0.71 | GFRA3 (0.43) | CHRNB2CHRNA4ALDH1A1TRPM5CHRNA7 | |
| SCHEMBL18094367 | 0.71 | GFRA3 (0.43) | CHRNB2CHRNA4ALDH1A1TRPM5CHRNA7 | |
| SCHEMBL3535473 | 0.71 | KDM1A (0.45) | ACHEKDM1A | |
| SCHEMBL22652225 | 0.71 | KDM1A (0.45) | ACHEKDM1A | |
| SCHEMBL18818329 | 0.69 | NOS3 (0.47) | CHRNB2CHRNA4ACHENOS3NOS1 | |
| SCHEMBL1719705 | 0.69 | ACHE (0.49) | ACHENOS3NOS1NOS2KDM1A | |
| SCHEMBL1061934 | 0.69 | ACHE (0.49) | ACHENOS3NOS1NOS2KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021217508-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF HIF2α AND THEIR METHODS OF USE | NOVARTIS AG (CH) | 2021-11-04 | — | — | WO | disclosed |