Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 3/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | CASP3 | P42574 | 6/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25812124 | 0.88 | NR1H4 (0.57) | NR1H4RAB9ANPC1CASP3FLT3 | |
| SCHEMBL23977683 | 0.82 | SMN1; SMN2 (0.47) | RAB9ANPC1SMN1; SMN2MEN1HPGD | |
| SCHEMBL23977684 | 0.80 | NR1H4 (0.38) | NR1H4RAB9ANPC1CASP3PKM | |
| SCHEMBL23977685 | 0.78 | TSHR (0.55) | NPC1SMN1; SMN2MEN1HPGDKMT2A | |
| SCHEMBL312801 | 0.77 | FLT3 (0.44) | NR1H4RAB9ANPC1CASP3PKM | |
| SCHEMBL25322090 | 0.76 | PIK3CA (0.38) | AHRNR1H4RAB9ANPC1FLT3 | |
| SCHEMBL15288131 | 0.74 | FYN (0.55) | AHRRAB9ANPC1FLT3SMN1; SMN2 | |
| SCHEMBL3849418 | 0.73 | NR1H4 (0.52) | NR1H4RAB9ANPC1PKMFLT3 | |
| SCHEMBL25813764 | 0.73 | NPC1 (0.45) | NR1H4RAB9ANPC1CASP3PKM | |
| SCHEMBL12998313 | 0.73 | PIK3CA (0.48) | FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219893-A1 | Krüppel-Like Factor 15 (KLF15) Small Molecule Agonists in Kidney Disease | US GOV VETERANS AFFAIRS (US) | 2023-07-13 | — | — | US | disclosed |
| US-20230219893-A1 | Krüppel-Like Factor 15 (KLF15) Small Molecule Agonists in Kidney Disease | US GOV VETERANS AFFAIRS (US) | 2023-07-13 | — | — | US | disclosed |
| US-11643394-B2 | Krüppel-like factor 15 (KLF15) small molecule agonists in kidney disease | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2023-05-09 | — | — | US | disclosed |
| US-11643394-B2 | Krüppel-like factor 15 (KLF15) small molecule agonists in kidney disease | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2023-05-09 | — | — | US | disclosed |
| WO-2021222637-A1 | KRÜPPEL-LIKE FACTOR 15 (KLF15) SMALL MOLECULE AGONISTS IN KIDNEY DISEASE | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (US) | 2021-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11643394-B2 | Krüppel-like factor 15 (KLF15) small molecule agonists in kidney disease | KIF15, KLF5, KLF10 | AHR 1053/4885NR1H4 1765/4885RAB9A 1697/4885 |
| US-20230219893-A1 | Krüppel-Like Factor 15 (KLF15) Small Molecule Agonists in Kidney Disease | KIF15, KLF5, KLF10 | AHR 1053/4885NR1H4 1765/4885RAB9A 1697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.