Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13079899 | 0.84 | PIM1 (0.39) | L3MBTL1ALDH1A1KDM4ECYP3A4CYP2C19 | |
| SCHEMBL19563032 | 0.81 | HTR1B (0.51) | HSP90AA1HSP90AB1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL4523648 | 0.81 | ALDH1A1 (0.47) | HSP90AA1HSP90AB1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL23977878 | 0.80 | ALDH1A1 (0.40) | HSP90AA1HSP90AB1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL8570866 | 0.80 | PTPN1 (0.41) | HSP90AA1HSP90AB1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL5376369 | 0.79 | MAPT (0.47) | HSP90AA1HSP90AB1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL23977889 | 0.77 | SMN1; SMN2 (0.39) | HSP90AA1HSP90AB1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL10762652 | 0.77 | ALDH1A1 (0.45) | L3MBTL1ALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL16959006 | 0.76 | MRGPRX4 (0.37) | HSP90AA1HSP90AB1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL26099384 | 0.76 | CYP1A2 (0.49) | HSP90AA1HSP90AB1L3MBTL1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230136562-A1 | SPIROUREA DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2023-05-04 | — | — | US | disclosed |
| US-20230136562-A1 | SPIROUREA DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2023-05-04 | — | — | US | disclosed |
| WO-2021219594-A1 | SPIROUREA DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2021-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230136562-A1 | SPIROUREA DERIVATIVES | KCNA7, PKD2, KCNN3 | HSP90AA1 3125/4885HSP90AB1 2642/4885L3MBTL1 4740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.