Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23977926 | 0.73 | MMP9 (0.49) | ALDH1A1CYP3A4 | |
| SCHEMBL25601919 | 0.73 | MMP9 (0.49) | ALDH1A1CYP3A4 | |
| SCHEMBL23977925 | 0.72 | MMP9 (0.48) | ALDH1A1CYP3A4 | |
| SCHEMBL23449212 | 0.72 | SPHK1 (0.46) | LMNAMAPTMAPK1ALDH1A1CTSK | |
| SCHEMBL30088787 | 0.70 | ALDH1A1 (0.55) | ALDH1A1CYP3A4HTTCYP2D6SMN1; SMN2 | |
| SCHEMBL23449236 | 0.69 | SPHK1 (0.55) | — | |
| SCHEMBL23449238 | 0.68 | NPSR1 (0.36) | CTSK | |
| SCHEMBL13609085 | 0.68 | PKM (0.68) | LMNAMAPTMAPK1ALDH1A1CYP3A4 | |
| SCHEMBL20328084 | 0.68 | TLR2 (0.44) | — | |
| SCHEMBL10311691 | 0.68 | LMNA (0.69) | LMNAMAPTMAPK1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222886-A1 | COMPOSITIONS AND METHODS TO TREAT POLYCYSTIC KIDNEY DISEASE | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2021-11-04 | — | — | WO | disclosed |