Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.60 |
| ▸ | CASP6 | P55212 | 1/20 | 0.54 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.48 |
| ▸ | BCL2 | P10415 | 1/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.48 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23978042 | 0.89 | MAOB (0.60) | MAOBCASP6HCAR3LMNATSHR | |
| SCHEMBL23978010 | 0.88 | NR4A2 (0.60) | MAOBCASP6LMNATSHRMAPT | |
| SCHEMBL4175596 | 0.81 | CASP6 (0.58) | CASP6HCAR3LMNATSHRMAPT | |
| SCHEMBL30014024 | 0.80 | MAOB (0.53) | MAOBCASP6HCAR3LMNATSHR | |
| SCHEMBL26963411 | 0.80 | MAOB (0.53) | MAOBCASP6HCAR3LMNATSHR | |
| SCHEMBL14212713 | 0.79 | CASP6 (0.55) | CASP6HCAR3LMNATSHRALOX5 | |
| SCHEMBL6950169 | 0.79 | CASP6 (0.55) | CASP6HCAR3LMNATSHR | |
| SCHEMBL13264670 | 0.79 | CASP6 (0.55) | CASP6HCAR3LMNATSHRMAPT | |
| SCHEMBL3125878 | 0.79 | MAOB (0.68) | MAOBTSHRMAPTNPC1RAB9A | |
| SCHEMBL16129686 | 0.78 | CASP6 (0.54) | CASP6HCAR3LMNATSHRALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11622970-B2 | BCL-2 inhibitors and their use as pharmaceuticals | Prelude Therapeutics Incorporation (US) | 2023-04-11 | — | — | US | disclosed |
| US-20210346405-A1 | BCL-2 INHIBITORS AND THEIR USE AS PHARMACEUTICALS | PRELUDE THERAPEUTICS INCORPORATED | 2021-11-11 | — | — | US | disclosed |
| US-20210346405-A1 | BCL-2 INHIBITORS AND THEIR USE AS PHARMACEUTICALS | PRELUDE THERAPEUTICS INCORPORATED | 2021-11-11 | — | — | US | disclosed |
| WO-2021222174-A1 | BCL-2 INHIBITORS AND THEIR USE AS PHARMACEUTICALS | PRELUDE THERAPEUTICS INCORPORATED (US) | 2021-11-04 | — | — | WO | disclosed |
| WO-2021222174-A1 | BCL-2 INHIBITORS AND THEIR USE AS PHARMACEUTICALS | PRELUDE THERAPEUTICS INCORPORATED (US) | 2021-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210346405-A1 | BCL-2 INHIBITORS AND THEIR USE AS PHARMACEUTICALS | BCL2, BCL2L2, BCL2L1 | MAOB 2890/4885CASP6 36/4885HCAR3 4362/4885 |
| US-11622970-B2 | BCL-2 inhibitors and their use as pharmaceuticals | BCL2, BCL2L2, BCL2L1 | MAOB 2890/4885CASP6 36/4885HCAR3 4362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.