Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 3/20 | 0.36 |
| ▸ | IGF1R | P08069 | 3/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 2/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 5/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 5/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.34 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.33 |
| ▸ | TACR3 | P29371 | 2/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23979058 | 0.90 | ITGB1 (0.39) | MAP3K5ITGB1ITGA5 | |
| SCHEMBL23978630 | 0.84 | FGFR1 (0.34) | INSRIGF1RALKFGFR1FGFR2 | |
| SCHEMBL24804639 | 0.83 | USP2 (0.41) | TAS1R3TAS1R1 | |
| SCHEMBL30279406 | 0.83 | USP2 (0.41) | TAS1R3TAS1R1 | |
| SCHEMBL24804864 | 0.83 | USP2 (0.41) | TAS1R3TAS1R1 | |
| SCHEMBL23978706 | 0.78 | MAP3K5 (0.45) | IGF1RALKFGFR1FGFR2FGFR4 | |
| SCHEMBL23979049 | 0.76 | P2RX3 (0.36) | TAS1R3TAS1R1ITGB1ITGA5 | |
| SCHEMBL23978691 | 0.75 | PRMT5 (0.36) | TAS1R3TAS1R1ITGB1ITGA5 | |
| SCHEMBL23978642 | 0.75 | LNPEP (0.39) | TAS1R3TAS1R1ITGB1ITGA5 | |
| SCHEMBL23978627 | 0.75 | MAP3K5 (0.44) | IGF1RFGFR1FGFR2FGFR4FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222789-A1 | INHIBITORS OF ALPHA 2 BETA 1 INTEGRIN AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-11-04 | — | — | WO | disclosed |