Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.42 |
| ▸ | ITGA5 | P08648 | 4/20 | 0.42 |
| ▸ | ITGAV | P06756 | 2/20 | 0.42 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.39 |
| ▸ | ITGAL | P20701 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23978644 | 0.91 | HPGD (0.45) | ALDH1A1MEN1KMT2AALOX15MAPK1 | |
| SCHEMBL30279395 | 0.81 | EPHX2 (0.49) | ALDH1A1ITGB1ITGAVITGA4HTT | |
| SCHEMBL26109531 | 0.81 | EPHX2 (0.49) | ALDH1A1ITGB1ITGAVITGA4HTT | |
| SCHEMBL23978998 | 0.81 | EPHX2 (0.49) | ALDH1A1ITGB1ITGAVITGA4HTT | |
| SCHEMBL23978657 | 0.81 | EPHX2 (0.49) | ALDH1A1ITGB1ITGAVITGA4HTT | |
| SCHEMBL23978563 | 0.81 | EPHX2 (0.49) | ALDH1A1ITGB1ITGAVITGA4HTT | |
| SCHEMBL24106071 | 0.79 | ITGB1 (0.59) | ITGB1ITGA5ITGAVITGA4ITGB2 | |
| SCHEMBL23979052 | 0.77 | ITGB2 (0.39) | ITGB1ITGA5ITGAVITGA4MEN1 | |
| SCHEMBL21376654 | 0.76 | ITGB2 (0.59) | ITGB1ITGA5ITGAVITGA4ITGB2 | |
| SCHEMBL23979071 | 0.75 | ALDH1A1 (0.39) | ALDH1A1ITGB1ITGA5ITGAVITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222789-A1 | INHIBITORS OF ALPHA 2 BETA 1 INTEGRIN AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-11-04 | — | — | WO | disclosed |