Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.32 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.32 |
| ▸ | EZH2 | Q15910 | 6/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23979012 | 0.88 | GRM5 (0.38) | GRM5KCNH2GRM2P2RX7ACKR3 | |
| SCHEMBL23978876 | 0.87 | GRM5 (0.41) | GRM5KCNH2GRM2P2RX7AOC3 | |
| SCHEMBL30279447 | 0.87 | GRM5 (0.41) | GRM5KCNH2GRM2P2RX7AOC3 | |
| SCHEMBL23978787 | 0.85 | GRM5 (0.36) | GRM5KCNH2GRM2P2RX7EZH2 | |
| SCHEMBL30279399 | 0.85 | GRM5 (0.36) | GRM5KCNH2GRM2P2RX7EZH2 | |
| SCHEMBL23978788 | 0.82 | GRM5 (0.36) | GRM5KCNH2GRM2P2RX7EZH2 | |
| SCHEMBL23978854 | 0.81 | DHPS (0.45) | GRM5 | |
| SCHEMBL23978872 | 0.78 | P2RX7 (0.46) | P2RX7 | |
| SCHEMBL23978860 | 0.69 | SMN1; SMN2 (0.44) | P2RX7 | |
| SCHEMBL23978853 | 0.69 | DHPS (0.44) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222789-A1 | INHIBITORS OF ALPHA 2 BETA 1 INTEGRIN AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-11-04 | — | — | WO | disclosed |