Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | EZH2 | Q15910 | 3/20 | 0.33 |
| ▸ | FPR1 | P21462 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23978787 | 1.00 | GRM5 (0.36) | GRM5SMN1; SMN2MAPTLMNAPKM | |
| SCHEMBL23978788 | 0.88 | GRM5 (0.36) | GRM5SMN1; SMN2ALDH1A1P2RX7EZH2 | |
| SCHEMBL23979012 | 0.87 | GRM5 (0.38) | GRM5SMN1; SMN2ALDH1A1P2RX7EZH2 | |
| SCHEMBL23978876 | 0.86 | GRM5 (0.41) | GRM5SMN1; SMN2ALDH1A1P2RX7AOC3 | |
| SCHEMBL30279447 | 0.86 | GRM5 (0.41) | GRM5SMN1; SMN2ALDH1A1P2RX7AOC3 | |
| SCHEMBL23978879 | 0.85 | GRM5 (0.37) | GRM5P2RX7EZH2AOC3KCNH2 | |
| SCHEMBL30279363 | 0.82 | SMN1; SMN2 (0.32) | SMN1; SMN2MAPTLMNAPKMALDH1A1 | |
| SCHEMBL23978802 | 0.82 | SMN1; SMN2 (0.32) | SMN1; SMN2MAPTLMNAPKMALDH1A1 | |
| SCHEMBL23978723 | 0.81 | SMN1; SMN2 (0.52) | GRM5SMN1; SMN2MAPTLMNAPKM | |
| SCHEMBL10129825 | 0.81 | ALDH1A1 (0.45) | SMN1; SMN2MAPTLMNAPKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115916176-A | Inhibitors of alpha 2 beta 1 integrin and methods of use thereof | 加利福尼亚大学董事会 | 2023-04-04 | — | — | CN | disclosed |
| EP-4142707-A1 | INHIBITORS OF ALPHA 2 BETA 1 INTEGRIN AND METHODS OF USE THEREOF | The Regents of the University of California (US) | 2023-03-08 | — | — | EP | disclosed |