Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 10/20 | 0.41 |
| ▸ | ITGA5 | P08648 | 5/20 | 0.41 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.39 |
| ▸ | ITGAL | P20701 | 3/20 | 0.39 |
| ▸ | GRN | P28799 | 1/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 5/20 | 0.36 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.36 |
| ▸ | ITGAV | P06756 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ITGB8 | P26012 | 2/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23978748 | 0.78 | ALDH1A1 (0.47) | ITGB2ICAM1ITGAL | |
| SCHEMBL26109901 | 0.78 | ALDH1A1 (0.47) | ITGB2ICAM1ITGAL | |
| SCHEMBL30279438 | 0.78 | ALDH1A1 (0.47) | ITGB2ICAM1ITGAL | |
| SCHEMBL23978933 | 0.78 | ALDH1A1 (0.47) | ITGB2ICAM1ITGAL | |
| SCHEMBL23978982 | 0.77 | ITGAL (0.39) | ITGB1ITGA5ITGB2ICAM1ITGAL | |
| SCHEMBL21376654 | 0.76 | ITGB2 (0.59) | ITGB1ITGA5ITGB2ICAM1ITGAL | |
| SCHEMBL23979052 | 0.75 | ITGB2 (0.39) | ITGB1ITGA5ITGB2ICAM1ITGAL | |
| SCHEMBL23978654 | 0.75 | ALDH1A1 (0.42) | SMN1; SMN2ITGB1ITGA5ITGB2ICAM1 | |
| SCHEMBL23979058 | 0.72 | ITGB1 (0.39) | ITGB1ITGA5ITGB2ICAM1ITGAL | |
| SCHEMBL30279423 | 0.70 | USP2 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222789-A1 | INHIBITORS OF ALPHA 2 BETA 1 INTEGRIN AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-11-04 | — | — | WO | disclosed |