Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | PKM | P14618 | 3/20 | 0.40 |
| ▸ | DHPS | P49366 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23978854 | 0.92 | DHPS (0.45) | ALDH1A1MAPTSMN1; SMN2LMNAPKM | |
| SCHEMBL23978811 | 0.89 | P2RX7 (0.45) | P2RX7ALDH1A1HPGDMAPTCYP2C9 | |
| SCHEMBL30279386 | 0.89 | P2RX7 (0.48) | P2RX7ALDH1A1HPGDMAPTCYP2C9 | |
| SCHEMBL23978798 | 0.89 | P2RX7 (0.48) | P2RX7ALDH1A1HPGDMAPTCYP2C9 | |
| SCHEMBL30279364 | 0.87 | SMN1; SMN2 (0.47) | P2RX7ALDH1A1HPGDMAPTCYP2C9 | |
| SCHEMBL30279365 | 0.87 | SMN1; SMN2 (0.47) | P2RX7ALDH1A1HPGDMAPTCYP2C9 | |
| SCHEMBL23978808 | 0.87 | SMN1; SMN2 (0.47) | P2RX7ALDH1A1HPGDMAPTCYP2C9 | |
| SCHEMBL30279428 | 0.80 | DHPS (0.48) | ALDH1A1MAPTCYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL23978727 | 0.80 | DHPS (0.48) | ALDH1A1MAPTCYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL23978853 | 0.80 | DHPS (0.44) | ALDH1A1MAPTSMN1; SMN2LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222789-A1 | INHIBITORS OF ALPHA 2 BETA 1 INTEGRIN AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-11-04 | — | — | WO | disclosed |