Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 2/20 | 0.43 |
| ▸ | DHFR | P00374 | 2/20 | 0.39 |
| ▸ | SLC19A1 | P41440 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SDCBP | O00560 | 1/20 | 0.37 |
| ▸ | SDC2 | P34741 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25742155 | 0.74 | LMNA (0.42) | LMNASDCBPSDC2MEN1KMT2A | |
| SCHEMBL27262176 | 0.72 | MAPT (0.33) | TYMSMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL27318763 | 0.72 | LMNA (0.46) | LMNASDCBPSDC2MEN1KMT2A | |
| SCHEMBL25467046 | 0.72 | LMNA (0.46) | LMNASDCBPSDC2MEN1KMT2A | |
| SCHEMBL23986739 | 0.72 | LMNA (0.41) | LMNASDCBPSDC2MEN1KMT2A | |
| SCHEMBL23729223 | 0.72 | LMNA (0.44) | LMNASDCBPSDC2MEN1KMT2A | |
| SCHEMBL23129018 | 0.71 | LMNA (0.43) | LMNASDCBPSDC2MEN1KMT2A | |
| SCHEMBL24822402 | 0.70 | RAB9A (0.44) | LMNAMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL24078844 | 0.69 | SLC6A2 (0.42) | LMNAMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL24701178 | 0.68 | LMNA (0.43) | LMNAMEN1KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222542-A1 | 5-AMINO-2-PIPERIDINON-3-YL-1-OXOISOINDOLINE DERIVATIVES FOR DEGRADATION OF IKZF2 DEGRADERS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-11-04 | — | — | WO | disclosed |