Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | HTR2C | P28335 | 3/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | PNMT | P11086 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23987337 | 0.81 | HTR1A (0.30) | — | |
| SCHEMBL8901220 | 0.73 | ADRA2A (0.38) | HTR2AHTR2CHTR2BPNMT | |
| SCHEMBL23987301 | 0.69 | HTR1A (0.39) | — | |
| SCHEMBL2159326 | 0.68 | HTR2A (0.37) | HTR2AHTR2CHTR2B | |
| SCHEMBL23977277 | 0.68 | VHL (0.44) | — | |
| SCHEMBL30888639 | 0.67 | NOTUM (0.32) | — | |
| SCHEMBL10947213 | 0.65 | HTR2A (0.34) | HTR2AHTR2CHTR2B | |
| SCHEMBL12124201 | 0.65 | — | — | |
| SCHEMBL30714304 | 0.63 | — | — | |
| SCHEMBL30714131 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021220170-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF HIF2-ALPHA AND THEIR METHODS OF USE | NOVARTIS AG (CH) | 2021-11-04 | — | — | WO | disclosed |