Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.31 |
| ▸ | BAD | Q92934 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4104527 | 0.76 | HPGD (0.38) | HTR1AADRA2ASLC6A2SLC6A4TSHR | |
| SCHEMBL8581327 | 0.76 | HTR1A (0.41) | HTR1AADRA2ASLC6A2SLC6A4TSHR | |
| SCHEMBL7526110 | 0.76 | BCL2L1 (0.48) | HTR1AADRA2ASLC6A2SLC6A4TSHR | |
| SCHEMBL23979971 | 0.76 | HTR1A (0.38) | HTR1AADRA2ASLC6A2SLC6A4TSHR | |
| SCHEMBL18297576 | 0.76 | HTR1A (0.38) | HTR1AADRA2ASLC6A2SLC6A4TSHR | |
| SCHEMBL8901220 | 0.76 | ADRA2A (0.38) | HTR1AADRA2ASLC6A2SLC6A4TSHR | |
| SCHEMBL7426602 | 0.72 | ALDH1A1 (0.40) | HTR1AADRA2ASLC6A2SLC6A4TSHR | |
| SCHEMBL9409715 | 0.72 | HTR1A (0.41) | HTR1AADRA2ASLC6A2SLC6A4TSHR | |
| SCHEMBL13532968 | 0.72 | SLC6A2 (0.41) | HTR1AADRA2ASLC6A2SLC6A4TSHR | |
| SCHEMBL14691708 | 0.72 | RYR2 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021220170-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF HIF2-ALPHA AND THEIR METHODS OF USE | NOVARTIS AG (CH) | 2021-11-04 | — | — | WO | disclosed |