Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 2/20 | 0.47 |
| ▸ | TEK | Q02763 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | TGM2 | P21980 | 3/20 | 0.46 |
| ▸ | BTK | Q06187 | 3/20 | 0.45 |
| ▸ | IDH2 | P48735 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | FBP1 | P09467 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23988607 | 0.92 | PGR (0.54) | EPHB4TEKKDRPGRPKM | |
| SCHEMBL23988635 | 0.89 | BTK (0.52) | PGRPKMTGM2BTKLMNA | |
| SCHEMBL20885030 | 0.86 | LMNA (0.57) | EPHB4TEKKDRCA2TGM2 | |
| SCHEMBL9568677 | 0.83 | TGM2 (0.58) | PKMTGM2BTKAURKAAURKB | |
| SCHEMBL17660300 | 0.83 | EPHB4 (0.61) | EPHB4TEKKDRCA2TGM2 | |
| SCHEMBL23988636 | 0.81 | EGFR (0.49) | PKMTGM2BTKIDH2PIK3CD | |
| SCHEMBL9568796 | 0.81 | TGM2 (0.58) | PGRPKMTGM2MEN1KMT2A | |
| SCHEMBL20885062 | 0.81 | TGM2 (0.55) | EPHB4TEKKDRCA2TGM2 | |
| SCHEMBL9568733 | 0.80 | BTK (0.63) | CA2TGM2BTKPIK3CDAURKA | |
| SCHEMBL23988609 | 0.80 | BTK (0.47) | CA2TGM2BTKPIK3CDPIK3C2G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11155556-B2 | Pyrimido-diazepinone kinase scaffold compounds and methods for treating PI3K-mediated disorders | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11155556-B2 | Pyrimido-diazepinone kinase scaffold compounds and methods for treating PI3K-mediated disorders | PI4KA, PIK3CA, PI4KB | EPHB4 1972/4885TEK 1762/4885KDR 834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.