Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.46 |
| ▸ | HTR7 | P34969 | 8/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | UCHL1 | P09936 | 3/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | HTR6 | P50406 | 3/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.42 |
| ▸ | CTSK | P43235 | 5/20 | 0.42 |
| ▸ | CTSL | P07711 | 3/20 | 0.42 |
| ▸ | CTSB | P07858 | 4/20 | 0.41 |
| ▸ | CTSS | P25774 | 3/20 | 0.41 |
| ▸ | CTSC | P53634 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20885013 | 0.83 | KMT2A (0.49) | HTR1AHTR7LMNAALDH1A1KMT2A | |
| SCHEMBL14349658 | 0.82 | ALDH1A1 (0.56) | HTR1AHTR7LMNAALDH1A1KMT2A | |
| SCHEMBL104506 | 0.79 | ALDH1A1 (0.58) | HTR1AHTR7LMNAALDH1A1KMT2A | |
| SCHEMBL26723906 | 0.76 | UCHL1 (0.53) | HTR1AHTR7ALDH1A1UCHL1USP30 | |
| SCHEMBL20885021 | 0.75 | LMNA (0.49) | HTR1AHTR7LMNAALDH1A1KMT2A | |
| SCHEMBL13400105 | 0.71 | ALDH1A1 (0.56) | LMNAALDH1A1KMT2A | |
| SCHEMBL26727091 | 0.70 | HTR1A (0.49) | HTR1AHTR7LMNAALDH1A1DRD2 | |
| SCHEMBL1710760 | 0.69 | ALDH1A1 (0.56) | LMNAALDH1A1KMT2A | |
| SCHEMBL1722336 | 0.69 | ALDH1A1 (0.53) | LMNAALDH1A1KMT2A | |
| SCHEMBL20885018 | 0.68 | BCL9 (0.51) | LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11155556-B2 | Pyrimido-diazepinone kinase scaffold compounds and methods for treating PI3K-mediated disorders | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11155556-B2 | Pyrimido-diazepinone kinase scaffold compounds and methods for treating PI3K-mediated disorders | PI4KA, PIK3CA, PI4KB | HTR1A 1537/4885HTR7 1658/4885LMNA 2983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.