Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.50 |
| ▸ | HTR2B | P41595 | 3/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 6/20 | 0.48 |
| ▸ | DRD2 | P14416 | 5/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7101418 | 0.84 | HTR2C (0.50) | HTR2CHTR2BSLC6A4SLC6A3SLC6A2 | |
| SCHEMBL7101414 | 0.84 | HTR2C (0.50) | HTR2CHTR2BSLC6A4SLC6A3SLC6A2 | |
| SCHEMBL23993008 | 0.76 | CHRNB2 (0.45) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL23993602 | 0.75 | DRD3 (0.48) | HTR2CHTR2BDRD3DRD2CYP2D6 | |
| SCHEMBL23995536 | 0.75 | HTR2C (0.68) | HTR2CHTR2BSLC6A4SLC6A3KDM1A | |
| SCHEMBL22335081 | 0.75 | HTR2C (0.68) | HTR2CHTR2BSLC6A4SLC6A3DRD3 | |
| SCHEMBL20205057 | 0.75 | HTR2C (0.68) | HTR2CHTR2BSLC6A4SLC6A3KDM1A | |
| SCHEMBL22335135 | 0.75 | HTR2C (0.70) | HTR2CHTR2BSLC6A4SLC6A3DRD2 | |
| SCHEMBL23993565 | 0.74 | SLC6A4 (0.49) | HTR2CHTR2BSLC6A4SLC6A3SLC6A2 | |
| SCHEMBL4851455 | 0.74 | MAOB (0.61) | HTR2CHTR2BSLC6A4SLC6A3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222522-A1 | CD73 INHIBITING 2,4-DIOXOPYRIMIDINE COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2021-11-04 | — | — | WO | disclosed |