Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LYPLA1 | O75608 | 1/20 | 0.37 |
| ▸ | LYPLA2 | O95372 | 1/20 | 0.37 |
| ▸ | LIPE | Q05469 | 1/20 | 0.37 |
| ▸ | TRPV6 | Q9H1D0 | 4/20 | 0.35 |
| ▸ | ORAI1 | Q96D31 | 4/20 | 0.35 |
| ▸ | ORAI2 | Q96SN7 | 4/20 | 0.35 |
| ▸ | ORAI3 | Q9BRQ5 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.30 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2400633 | 0.78 | TRPV6 (0.58) | TSHRLYPLA1LYPLA2LIPETRPV6 | |
| SCHEMBL2407168 | 0.78 | TRPV6 (0.44) | TSHRLYPLA1LYPLA2LIPETRPV6 | |
| SCHEMBL2398463 | 0.78 | TSHR (0.38) | TSHRLYPLA1LYPLA2LIPEMEN1 | |
| SCHEMBL3274031 | 0.75 | TRPV6 (0.41) | TSHRLYPLA1LYPLA2TRPV6ORAI1 | |
| SCHEMBL2399046 | 0.75 | ORAI1 (0.41) | TSHRLYPLA1LYPLA2TRPV6ORAI1 | |
| SCHEMBL14503424 | 0.72 | TSHR (0.54) | TSHRLYPLA1LYPLA2TRPV6ORAI1 | |
| SCHEMBL29957976 | 0.72 | TSHR (0.48) | TSHRLYPLA1LYPLA2LIPEMAOB | |
| SCHEMBL14503428 | 0.71 | TSHR (0.52) | TSHRLYPLA1LYPLA2TRPV6ORAI1 | |
| SCHEMBL16151496 | 0.71 | TRPV6 (0.55) | TSHRLYPLA1LYPLA2TRPV6ORAI1 | |
| SCHEMBL14503413 | 0.71 | ORAI1 (0.63) | TSHRLYPLA1LYPLA2TRPV6ORAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1961756-B1 | NOVEL BISBORON COMPOUND | JAPAN SCIENCE & TECH AGENCY (JP) | 2016-04-27 | — | — | EP | claimed |
| US-8017809-B2 | Bisboron compound | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2011-09-13 | — | — | US | claimed |
| US-20100087645-A1 | NOVEL BISBORON COMPOUND | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2010-04-08 | — | — | US | claimed |
| EP-1961756-A1 | NOVEL BISBORON COMPOUND | Japan Science and Technology Agency (JP) | 2008-08-27 | — | — | EP | claimed |
| EP-1961756-B1 | NOVEL BISBORON COMPOUND | JAPAN SCIENCE & TECH AGENCY (JP) | 2016-04-27 | — | — | EP | disclosed |
| US-8017809-B2 | Bisboron compound | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2011-09-13 | — | — | US | disclosed |
| US-20100087645-A1 | NOVEL BISBORON COMPOUND | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2010-04-08 | — | — | US | disclosed |
| EP-1961756-A1 | NOVEL BISBORON COMPOUND | Japan Science and Technology Agency (JP) | 2008-08-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087645-A1 | NOVEL BISBORON COMPOUND | KCNMB4, CA2, NR0B2 | TSHR 977/4885LYPLA1 4548/4885LYPLA2 4342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.