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Sugi Predict / Targets / KCNMB4

KCNMB4

Calcium-activated potassium channel subunit beta-4 · Q86W47 · KCNMB4 on Sugi Atlas →

251 patent compounds predicted against KCNMB4, 210 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL29369035 SCHEMBL29369035 0.67 1/20
SCHEMBL29438822 SCHEMBL29438822 0.66 1/20
SCHEMBL29389059 SCHEMBL29389059 0.66 1/20
SCHEMBL29424808 SCHEMBL29424808 0.65 1/20
Vitri A Vitri A (SCHEMBL30132415) 0.64 1/20
SCHEMBL29462295 SCHEMBL29462295 0.63 1/20
SCHEMBL63125 SCHEMBL63125 0.63 1/20
SCHEMBL29467923 SCHEMBL29467923 0.63 1/20
SCHEMBL15669703 SCHEMBL15669703 0.63 1/20
SCHEMBL14840198 SCHEMBL14840198 0.62 1/20
Cycloviolacin O2 Cycloviolacin O2 (SCHEMBL30497729) 0.62 1/20
SCHEMBL29438955 SCHEMBL29438955 0.62 1/20
SCHEMBL29387182 SCHEMBL29387182 0.62 1/20
SCHEMBL29389145 SCHEMBL29389145 0.61 1/20
Insulin Detemir Insulin Detemir (SCHEMBL29350489) 0.61 1/20
SCHEMBL29385832 SCHEMBL29385832 0.61 1/20
SCHEMBL29352842 SCHEMBL29352842 0.60 1/20
SCHEMBL33618 SCHEMBL33618 0.59 1/20
SCHEMBL29607029 SCHEMBL29607029 0.59 1/20
SCHEMBL29356518 SCHEMBL29356518 0.59 1/20

Clinical trials — most relevant to KCNMB4 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Sulphonylurea Receptor Mutation and Responsiveness to Gliclazide - a Pilot Proof of Concept, Randomised Cross-over Study PHASE4COMPLETED
Effect of Amiodarone on the Procedure Outcome in Long-standing Persistent Atrial Fibrillation Undergoing Pulmonary Vein Antral Isolation PHASE3COMPLETED
A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy PHASE1/PHASE2RECRUITING
Mutation-specific Therapy for the Long QT Syndrome PHASE2COMPLETED
Calcium Channel Blockade in Primary Aldosteronism PHASE2COMPLETED
A Phase I, Open-Labeled, Single-Arm, Dose Escalation, Clinical and Pharmacology Study of Dichloroacetate (DCA) in Patients With Recurrent and/or Metastatic Solid Tumours PHASE1COMPLETED
Safety, Blood Levels and Effects of AUT00201 in Patients With MEAK PHASE1COMPLETED
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients. nanUNKNOWN
Genetic Determinants of Sudden Cardiac Death nanCOMPLETED
A Cohort Study on the Prognosis of Neonatal KCNQ2 Gene-associated Epileptic Encephalopathy nanUNKNOWN
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives nanUNKNOWN
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain. nanUNKNOWN
The Effects of the Anesthetic Drug Propofol on the Way the Heart Recovers Between Beats nanCOMPLETED
Qatar Cardiovascular Biorepository of AF Patients nanUNKNOWN
The Effects of the Anti Nausea Drugs Droperidol and Ondansetron on the Way the Heart Recovers Between Beats nanCOMPLETED
Role of Nitric Oxide in Diabetic Patients With Erectile Dysfunction nanCOMPLETED
The Natural History of TRPV4 Neuropathy nanRECRUITING
The Physiological Effects of Human Ether-a-go-go-Related Gene (hERG)Blockade on Metabolism nanCOMPLETED
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services nanUNKNOWN
Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome nanRECRUITING
Macrolides for KCNJ5 - Mutated Aldosterone-Producing Adenoma (MAPA) nanUNKNOWN
Transcriptomic Profile of Patients Treated With Different Modalities of Spinal Cord Stimulation nanUNKNOWN
Gene Study for Infantile Onset Diabetes nanUNKNOWN
Sodium Channel Splicing in Heart Failure Trial nanCOMPLETED
Targeting Potassium Channels to Reprogram Glioblastoma Microenvironment: in Vitro and in Vivo Studies nanUNKNOWN
Factors Affecting Salt Intake in Young Adults nanUNKNOWN
ST-segment Elevation as an AF Endophenotype nanCOMPLETED
Characteristics of Episodic Ataxia Syndrome nanCOMPLETED
Heart and Skeletal Muscle Problems in Neuroacanthocytosis nanCOMPLETED
Sodium Channel Splicing in Obstructive Sleep Apnea (SOCS-OSA) nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a KCNMB4 binder may also engage these)

ProteinNameSimilarity
Q9ESK8 — 1.000 Q9ESK8 →
Q9JIN6 — 0.998 Q9JIN6 →
Q811Q0 — 0.984 Q811Q0 →
Q9CZM9 — 0.981 Q9CZM9 →
Q9Y691 — 0.980 Q9Y691 →
Q8CIF6 — 0.964 Q8CIF6 →
D3ZEH5 — 0.962 D3ZEH5 →
Q6NYU2 — 0.961 Q6NYU2 →
Q5RF53 — 0.959 Q5RF53 →
P11456 — 0.959 P11456 →
Q3SZM3 — 0.958 Q3SZM3 →
Q6AY20 — 0.958 Q6AY20 →
Q969V5 — 0.958 Q969V5 →
Q58E26 — 0.958 Q58E26 →
Q28C34 — 0.957 Q28C34 →
Q8NBJ9 — 0.957 Q8NBJ9 →
Q4R7G8 — 0.956 Q4R7G8 →
A6NFY4 — 0.956 A6NFY4 →
Q8IWV8 — 0.956 Q8IWV8 →
Q0VBD0 — 0.956 Q0VBD0 →
A6H7H7 — 0.955 A6H7H7 →
Q8VCM5 — 0.955 Q8VCM5 →
Q3SYY9 — 0.955 Q3SYY9 →
P24668 — 0.955 P24668 →
Q9NX78 — 0.955 Q9NX78 →
Q8K0B2 — 0.954 Q8K0B2 →
Q3T0J1 — 0.954 Q3T0J1 →
CSGALNACT1 Chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.954 landscape →
F1QR43 — 0.954 F1QR43 →
Q5RBT8 — 0.954 Q5RBT8 →