Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.64 |
| ▸ | NPC1 | O15118 | 6/20 | 0.64 |
| ▸ | RAB9A | P51151 | 6/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 6/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.54 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21828989 | 0.91 | KMT2A (0.66) | KMT2ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL21828972 | 0.84 | MAPT (0.61) | KMT2ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL21828981 | 0.81 | MAPT (0.60) | KMT2ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL21829030 | 0.80 | NPC1 (0.68) | KMT2ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL21829023 | 0.79 | KMT2A (0.78) | KMT2ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL29124110 | 0.79 | NPC1 (1.00) | KMT2ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL21828987 | 0.76 | MAPT (0.69) | KMT2ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL17149669 | 0.75 | KMT2A (0.64) | KMT2ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL21829026 | 0.74 | KMT2A (0.56) | KMT2ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL4548097 | 0.74 | ABCG2 (0.65) | KMT2ANPC1RAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210347752-A1 | BENZAMIDE DERIVATIVES AS CGAS-STING PATHWAY AGONISTS | BARUCH S. BLUMBERG INSTITUTE | 2021-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210347752-A1 | BENZAMIDE DERIVATIVES AS CGAS-STING PATHWAY AGONISTS | STING1, CGAS, MAVS | KMT2A 2676/4885NPC1 1661/4885RAB9A 1646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.