Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21828989 | 0.85 | KMT2A (0.66) | MAPTALDH1A1SMN1; SMN2LMNANPC1 | |
| SCHEMBL24004518 | 0.84 | KMT2A (0.64) | MAPTALDH1A1SMN1; SMN2LMNANPC1 | |
| SCHEMBL21829026 | 0.81 | KMT2A (0.56) | MAPTALDH1A1SMN1; SMN2LMNANPC1 | |
| SCHEMBL21828987 | 0.80 | MAPT (0.69) | MAPTALDH1A1SMN1; SMN2LMNANPC1 | |
| SCHEMBL21829022 | 0.79 | KMT2A (0.69) | MAPTALDH1A1SMN1; SMN2LMNANPC1 | |
| SCHEMBL18572523 | 0.79 | KCNMA1 (0.63) | MAPTALDH1A1SMN1; SMN2LMNANPC1 | |
| SCHEMBL21829030 | 0.78 | NPC1 (0.68) | MAPTALDH1A1SMN1; SMN2NPC1KMT2A | |
| SCHEMBL26565632 | 0.77 | ALDH1A1 (0.58) | MAPTALDH1A1SMN1; SMN2LMNANPC1 | |
| SCHEMBL1351165 | 0.77 | ALDH1A1 (0.64) | MAPTALDH1A1SMN1; SMN2LMNANPC1 | |
| SCHEMBL21828981 | 0.76 | MAPT (0.60) | MAPTALDH1A1SMN1; SMN2LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210347752-A1 | BENZAMIDE DERIVATIVES AS CGAS-STING PATHWAY AGONISTS | BARUCH S. BLUMBERG INSTITUTE | 2021-11-11 | — | — | US | claimed |
| CN-112888688-A | Benzamide derivatives as CGAS-STING pathway agonists | 巴鲁克斯布伦博格研究所 | 2021-06-01 | — | — | CN | claimed |
| WO-2020072492-A1 | BENZAMIDE DERIVATIVES AS CGAS-STING PATHWAY AGONISTS | BARUCH S. BLUMBERG INSTITUTE (US) | 2020-04-09 | — | — | WO | claimed |
| US-12509436-B2 | Benzamide derivatives as cGAS-sting pathway agonists | BARUCH S. BLUMBERG INSTITUTE (US) | 2025-12-30 | — | — | US | disclosed |
| US-20210347752-A1 | BENZAMIDE DERIVATIVES AS CGAS-STING PATHWAY AGONISTS | BARUCH S. BLUMBERG INSTITUTE | 2021-11-11 | — | — | US | disclosed |
| US-20210347752-A1 | BENZAMIDE DERIVATIVES AS CGAS-STING PATHWAY AGONISTS | BARUCH S. BLUMBERG INSTITUTE | 2021-11-11 | — | — | US | disclosed |
| CN-112888688-A | Benzamide derivatives as CGAS-STING pathway agonists | 巴鲁克斯布伦博格研究所 | 2021-06-01 | — | — | CN | disclosed |
| WO-2020072492-A1 | BENZAMIDE DERIVATIVES AS CGAS-STING PATHWAY AGONISTS | BARUCH S. BLUMBERG INSTITUTE (US) | 2020-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12509436-B2 | Benzamide derivatives as cGAS-sting pathway agonists | STING1, CGAS, IFNAR1 | MAPT 4812/4885ALDH1A1 4236/4885SMN1; SMN2 4240/4885 |
| US-20210347752-A1 | BENZAMIDE DERIVATIVES AS CGAS-STING PATHWAY AGONISTS | STING1, CGAS, MAVS | MAPT 4381/4885ALDH1A1 3145/4885SMN1; SMN2 4096/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.