Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.34 |
| ▸ | ITGAL | P20701 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25478789 | 0.87 | P2RX7 (0.40) | P2RX7KMT2AMEN1ALDH1A1CYP3A4 | |
| SCHEMBL24005484 | 0.86 | P2RX7 (0.39) | P2RX7KMT2AMEN1CYP3A4CYP2C9 | |
| SCHEMBL25478787 | 0.85 | KMT2A (0.38) | KMT2ATACR1MEN1ALDH1A1LMNA | |
| SCHEMBL25613551 | 0.83 | ITGB2 (0.37) | KMT2ATACR1MEN1ALDH1A1LMNA | |
| SCHEMBL24005489 | 0.81 | P2RX7 (0.43) | P2RX7KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL25479247 | 0.80 | ALDH1A1 (0.49) | KMT2AMEN1ALDH1A1LMNAHPGD | |
| SCHEMBL24005860 | 0.80 | HTR2A (0.42) | KMT2AMEN1ALDH1A1LMNACYP1A2 | |
| SCHEMBL25480477 | 0.77 | HRH3 (0.33) | — | |
| SCHEMBL24333460 | 0.77 | P2RX7 (0.64) | P2RX7KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL24333207 | 0.77 | P2RX7 (0.64) | P2RX7KMT2AMEN1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023088167-A1 | COMPOUNDS AS BCL-2 INHIBITORS | FOCHON PHARMACEUTICALS, LTD. (CN) | 2023-05-25 | — | — | WO | disclosed |
| WO-2021223736-A1 | COMPOUNDS AS BCL-2 INHIBITORS | FOCHON PHARMACEUTICALS, LTD. (CN) | 2021-11-11 | — | — | WO | disclosed |