Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TEAD3 | Q99594 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4663055 | 0.82 | L3MBTL1 (0.50) | TSHRTDP1L3MBTL1TEAD3SMN1; SMN2 | |
| SCHEMBL721274 | 0.79 | EPHX2 (0.48) | TSHRTDP1L3MBTL1TEAD3SMN1; SMN2 | |
| SCHEMBL19040806 | 0.79 | L3MBTL1 (0.50) | TSHRTDP1L3MBTL1TEAD3SMN1; SMN2 | |
| SCHEMBL3484952 | 0.78 | TEAD3 (0.46) | TSHRTDP1L3MBTL1TEAD3SMN1; SMN2 | |
| SCHEMBL25796839 | 0.78 | TSHR (0.44) | TSHRTDP1L3MBTL1TEAD3SMN1; SMN2 | |
| SCHEMBL2640223 | 0.78 | TSHR (0.70) | TSHRTDP1L3MBTL1HRH4HRH3 | |
| SCHEMBL8621469 | 0.78 | TSHR (0.70) | TSHRTDP1L3MBTL1TEAD3HRH4 | |
| SCHEMBL291194 | 0.78 | SMN1; SMN2 (0.57) | TSHRTEAD3SMN1; SMN2HTTEPHX2 | |
| SCHEMBL14600308 | 0.77 | TSHR (0.56) | TSHRTDP1L3MBTL1TEAD3SMN1; SMN2 | |
| SCHEMBL2593113 | 0.77 | TSHR (0.56) | TSHRSMN1; SMN2HTTNAAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228527-A1 | STEREOSELECTIVE C9-C10 BOND FORMATION | TRUSTEES OF DARTMOUTH COLLEGE | 2024-07-11 | — | — | US | disclosed |
| US-20240228527-A1 | STEREOSELECTIVE C9-C10 BOND FORMATION | TRUSTEES OF DARTMOUTH COLLEGE | 2024-07-11 | — | — | US | disclosed |
| US-20230212215-A1 | GLUCOCORTICOID RECEPTOR MODULATORS | TRUSTEES OF DARTMOUTH COLLEG | 2023-07-06 | — | — | US | disclosed |
| US-20230212215-A1 | GLUCOCORTICOID RECEPTOR MODULATORS | TRUSTEES OF DARTMOUTH COLLEG | 2023-07-06 | — | — | US | disclosed |
| WO-2021226465-A1 | GLUCOCORTICOID RECEPTOR MODULATORS | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2021-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240228527-A1 | STEREOSELECTIVE C9-C10 BOND FORMATION | NR5A1, HSD17B11, ESRRA | TSHR 520/4885TDP1 4353/4885L3MBTL1 1547/4885 |
| US-20230212215-A1 | GLUCOCORTICOID RECEPTOR MODULATORS | NR3C1, NR3C2, MC2R | TSHR 76/4885TDP1 4576/4885L3MBTL1 2757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.