Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24007928 | 0.85 | HRH4 (0.38) | HRH4RECQLMAPK14 | |
| SCHEMBL24006762 | 0.82 | HRH4 (0.37) | HRH4RECQLMAPK14 | |
| SCHEMBL24006702 | 0.74 | RECQL (0.35) | HRH4RECQLMAPK14 | |
| SCHEMBL24006855 | 0.72 | RECQL (0.32) | RECQL | |
| SCHEMBL24006703 | 0.72 | HRH4 (0.38) | HRH4RECQLMAPK14 | |
| SCHEMBL24006772 | 0.69 | — | — | |
| SCHEMBL7288273 | 0.68 | KEAP1 (0.48) | RECQL | |
| SCHEMBL7281400 | 0.67 | CES2 (0.42) | RECQLMAPK14 | |
| SCHEMBL24014110 | 0.67 | GCGR (0.34) | HRH4RECQLMAPK14 | |
| SCHEMBL18375724 | 0.65 | SLC6A4 (0.45) | RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021226208-A2 | HETEROAROMATIC MACROCYCLIC ETHER CHEMOTHERAPEUTIC AGENTS | NUVALENT, INC. (US) | 2021-11-11 | — | — | WO | disclosed |