Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.34 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24009189 | 0.84 | DRD2 (0.43) | SMN1; SMN2 | |
| SCHEMBL12935790 | 0.83 | SMN1; SMN2 (0.45) | SMN1; SMN2HSD11B1SMYD3HRH3EPHX1 | |
| SCHEMBL26400721 | 0.80 | CYP2D6 (0.46) | SMN1; SMN2KDM4EHRH3 | |
| SCHEMBL14971537 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2HSD11B1SMYD3EPHX1EPHX2 | |
| SCHEMBL24009201 | 0.78 | — | — | |
| SCHEMBL20609863 | 0.77 | SMN1; SMN2 (0.48) | SMN1; SMN2HSD11B1SMYD3HRH3EPHX1 | |
| SCHEMBL24837374 | 0.76 | GPR119 (0.37) | SMN1; SMN2HTR2A | |
| SCHEMBL24837384 | 0.76 | CYP2D6 (0.39) | SMN1; SMN2HSD11B1KDM4E | |
| SCHEMBL19544965 | 0.76 | NCF1 (0.34) | MEN1KMT2AHTR2A | |
| SCHEMBL15998447 | 0.75 | SMN1; SMN2 (0.38) | SMN1; SMN2HSD11B1SMYD3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021225969-A1 | IMINO SULFANONE INHIBITORS OF ENPP1 | VOLASTRA THERAPEUTICS, INC. (US) | 2021-11-11 | — | — | WO | disclosed |